Diurnal 5HT Production and Melatonin Formation
A number of studies have demonstrated an increase in TPH activity in rat pineals at night. 3, 4, 6 It is also well established that betaadrenergic signaling activates the increase in TPH activity, 4, 7 and 5HT synthesis. 1 Furthermore, purified rat brain TPH is phosphorylated in vitro by cAMPdependent protein kinase (PKA), 6, 8 and betaadrenergic signaling leads to an increase in ...